November 20th, 2021
| Place | Name | Bib # | Age | Gender | Hometown | Time | Pace | Age Group Result |
|---|---|---|---|---|---|---|---|---|
| 37 | Kathryn Mustard | 1152 | 46 | F | Roanoke VA | 53:49.0 | 8:41/M | 1:F 45-49 |
| 81 | Leigh Ramsey | 1161 | 47 | F | Roanoke | 1:00:34.2 | 9:46/M | 2:F 45-49 |
| 83 | Ilona Parks | 1033 | 45 | F | Roanoke VA | 1:00:44.7 | 9:48/M | 3:F 45-49 |
| 85 | Melissa Gerth | 1113 | 46 | F | Blacksburg VA | 1:00:53.0 | 9:49/M | 4:F 45-49 |
| 87 | Nicole Coleman | 1088 | 46 | F | 1:01:27.3 | 9:55/M | 5:F 45-49 | |
| 119 | Laura Zebosky | 1009 | 47 | F | Roanoke VA | 1:10:46.2 | 11:25/M | 6:F 45-49 |
| 139 | Amy Bramblett-Robinson | 1158 | 49 | F | Troutville VA | 1:24:56.8 | 13:42/M | 7:F 45-49 |
| 150 | Tanya Culbert | 1134 | 46 | F | 1:35:36.7 | 15:25/M | 8:F 45-49 |