September 4th, 2021
| Place | Name | Bib # | Age | Gender | Hometown | Time | Pace | Age Group Result |
|---|---|---|---|---|---|---|---|---|
| 33 | Emily Carter | 117 | 41 | F | Greensboro NC | 3:10:07.8 | 11:53/M | 1:F 40-44 |
| 35 | Robin Mehler | 178 | 44 | F | Asheville NC | 3:13:35.8 | 12:06/M | 2:F 40-44 |
| 37 | Missy Bradley | 109 | 44 | F | Bedford VA | 3:15:33.0 | 12:13/M | 3:F 40-44 |
| 38 | Lisa Hazlett | 152 | 44 | F | Kingsport TN | 3:16:08.9 | 12:16/M | 4:F 40-44 |
| 54 | Rachel Wade | 232 | 42 | F | Kingsport TN | 3:30:50.8 | 13:11/M | 5:F 40-44 |
| 70 | Amanda Tipton | 225 | 44 | F | Kingsport TN | 3:46:54.7 | 14:11/M | 6:F 40-44 |
| 80 | Cindi Spaulding | 214 | 42 | F | 3:53:45.0 | 14:37/M | 7:F 40-44 | |
| 90 | Beth Miletich | 180 | 44 | F | Cavespring VA | 4:04:38.4 | 15:17/M | 8:F 40-44 |
| 95 | Victoria Mininger | 181 | 44 | F | Waynesboro VA | 4:15:24.3 | 15:58/M | 9:F 40-44 |
| 109 | Rene Cornette | 125 | 40 | F | Grays Knob KY | 5:02:44.3 | 18:55/M | 10:F 40-44 |