May 7th, 2022
| Place | Name | Bib # | Age | Gender | Hometown | Time | Pace | Age Group Result |
|---|---|---|---|---|---|---|---|---|
| 35 | Stacy Dawson | 554 | 48 | F | Rustburg VA | 1:13:16.63 | 11:16/M | 1:F 45-49 |
| 36 | Ilona Parks | 520 | 46 | F | Roanoke VA | 1:13:25.99 | 11:18/M | 2:F 45-49 |
| 54 | Kim Stafford | 543 | 46 | F | Roanoke VA | 1:24:01.57 | 12:56/M | 3:F 45-49 |
| 64 | Shannon Honaker | 587 | 45 | F | Radford VA | 1:32:47.49 | 14:17/M | 4:F 45-49 |
| 65 | Annabelle Soete | 589 | 49 | F | Forest VA | 1:35:30.42 | 14:42/M | 5:F 45-49 |
| 71 | Sherry Colvin | 523 | 45 | F | Roanoke VA | 1:45:46.36 | 16:16/M | 6:F 45-49 |
| 73 | Bridget Melvin | 538 | 46 | F | Buchanan VA | 1:46:19.63 | 16:21/M | 7:F 45-49 |
| 82 | Kat Fillpot | 512 | 46 | F | Roanoke VA | 2:54:29.57 | 26:51/M | 8:F 45-49 |