November 20th, 2021
| Place | Name | Bib # | Age | Gender | Hometown | Time | Pace | Age Group Result |
|---|---|---|---|---|---|---|---|---|
| 100 | Kim Kitts | 65 | 49 | F | Christiansburg VA | 1:53:47.6 | 8:41/M | 1:F 45-49 |
| 124 | Mattie Radford | 193 | 46 | F | Roanoke VA | 1:57:57.8 | 9:00/M | 2:F 45-49 |
| 135 | Ruth Woody | 250 | 47 | F | Boones Mill VA | 1:59:27.8 | 9:07/M | 3:F 45-49 |
| 161 | Shannon Ingrassia | 333 | 45 | F | Roanoke VA | 2:05:07.2 | 9:33/M | 4:F 45-49 |
| 175 | Sunshine Richards | 229 | 47 | F | Moneta VA | 2:06:09.1 | 9:38/M | 5:F 45-49 |
| 198 | Kristi Turner | 230 | 46 | F | Midlothian VA | 2:11:34.1 | 10:03/M | 6:F 45-49 |
| 208 | Tanya Leroith | 314 | 49 | F | Blacksburg VA | 2:15:25.6 | 10:20/M | 7:F 45-49 |
| 217 | Melissa Leaf | 175 | 45 | F | Roanoke VA | 2:17:19.8 | 10:29/M | 8:F 45-49 |
| 263 | Jen Osburn | 196 | 46 | F | Salem VA | 2:31:48.0 | 11:35/M | 9:F 45-49 |
| 267 | Shannon Honaker | 255 | 45 | F | Radford VA | 2:34:20.5 | 11:47/M | 10:F 45-49 |
| 308 | Audrey Kern | 214 | 49 | F | Moneta VA | 3:00:54.6 | 13:49/M | 11:F 45-49 |
| 319 | Shannon Via | 218 | 47 | F | Hardy VA | 3:42:57.1 | 17:01/M | 12:F 45-49 |